Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview and Implications for Risk Assessment

EPA is announcing a 45-day public comment period for the draft document titled, "Lymphohematopoietic Cancers Induced by Chemicals and Other Agents: Overview and Implications for Risk Assessment" (EPA/600/ R-10/095A). The draft document was prepared by the National Center for Environmental Assessment within EPA's Office of Research and Development. The draft document provides an overview of the types and mechanisms underlying the lymphohematopoietic cancers induced by chemical agents and radiation in humans, with a primary emphasis on leukemia and leukemia-inducing agents. In addition, the document also focuses on how mechanistic information on human leukemia-inducing agents can inform risk assessment. EPA is releasing this draft document solely for the purpose of pre- dissemination peer review under applicable information quality guidelines. This draft document has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency policy or determination. All public comments received will be provided to the peer reviewers at the beginning of the review process.