Formation of rippled β-sheets from mixed chirality linear and cyclic peptides—new structural motifs based on the pauling-corey rippled β-sheet

<p>Shown here is the first mixed chirality macrocycle that is intrinsically locked into a rippled sheet configuration. The rippled β-sheet is a structural motif formed by certain racemic peptides that is distinct from the commonly known pleated β-sheet.</p>. Authors: Hazari, Amaruka [Dept. of Chemistry and Biochemistry, UCSC, 1156 High Street, Santa Cruz, CA, 95064, USA]; Sawaya, Michael R. [Dept. of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East Box 951569, Los Angeles, CA, 90095-1569, USA]; Lee, Hyeonju [Materials and Process Simulation Center, California Institute of Technology, Pasadena, CA, 91125, USA, Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-Ro, Yuseong-Gu, Daejeon, 34141, Republic of Korea]; Sajimon, Maria [Dept. of Chemistry and Biochemistry, UCSC, 1156 High Street, Santa Cruz, CA, 95064, USA]; Kim, Hyungjun [Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-Ro, Yuseong-Gu, Daejeon, 34141, Republic of Korea]