Structural and mechanistic insights into KslB, a bacterial Pictet–Spenglerase in kitasetaline biosynthesis

<p>Stereoselectivity of the Pictet–Spengler reaction catalyzed by KslB resolved by the crystal structure of enzyme-product complex.</p>. Authors: Kim, Wantae [McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, USA]; Zheng, Ziyang [Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, USA] (ORCID:0009000497004178); Kim, Kangsan [Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas 78712, USA] (ORCID:0009000031333615); Lee, Yu-Hsuan [Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, USA] (ORCID:0009000509157172); Liu, Hung-wen [Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, USA, Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, USA] (ORCID:0000000189534794)